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Antibiotics are suspected to diminish oral contraceptive efficacy by two main mechanisms: induction of the cytochrome P450 group of hepatic microsomal enzymes and interference with enterohepatic cycling of ethinylestradiol ( 6) ( Table 1 ). Augmentin doesn't decrease the effectiveness of the Nexplanon implant because there is no drug interaction between them. Now, we have got the complete detailed explanation and answer for everyone, who is interested! Its worth noting that both antibiotics are very rarely prescribed Nope! But there are reports that it may decrease the effects of the birth control pills and an unwanted pregnancy might happen Does augmentin affect birth control? Certain HIV medicines can also impact birth control negatively Some of these medications increase the breakdown of the hormones in birth control pills. If you are on an implant and have taken Augmentin, you can trust that the implant is working for you. 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